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istradefylline will enhance the stage or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.dabrafenib will lessen the level or influence of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3